人才队伍
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刘海鹰
个人简介
中国医学科学院/北京协和医学院病原生物学研究所党委副书记、纪委书记、课题组组长。全国结核病防治综合质量控制专家指导委员会委员、中国免疫学会感染免疫分会委员、中国防痨协会结核病基础专业分会常委。《中华结核和呼吸杂志》和《结核与肺部疾病杂志》编委。
主要研究方向是感染、炎症与免疫机制研究。主持或参与国家科技重大专项、国家重点研发计划、国家自然科学基金、医学与健康科技创新工程等多项国家级和院校级科研项目，参与多项战略咨询项目研究。在SCI收录杂志上发表学术论文30余篇；获得6项发明专利授权；获得中华医学科学技术奖二等奖（排名第五）、重大专项创新团队奖。
研究方向
结核病等我国重大传染病免疫机制及新型生物标识的研究。
科研项目
1. 国家重点研发计划（2021-2026），结核病新型诊断、治疗、干预手段及产品研发，课题骨干。
2. 中国医学科学院中央级公益性科研院所基本科研业务费（2020-2022），西藏自治区结核病流行菌株特征及致病特点研究，课题负责人。
3. 国家自然科学基金委员会面上项目（2021-2024），血管生成素2参与活动性肺结核免疫机制研究，课题负责人。
4. 中国工程院咨询研究项目(2019-2020 )，中国与法国等发达国家结核病防治体系的对比研究，课题骨干。
5. 国家外专局高端外国专家项目(2018-1019)，结核病新型分子标识研究，课题负责人。
6. 国家科技重大专项 (2017-2020)，菌阴结核病和结核分枝杆菌潜伏感染相关生物标志物研究，子课题负责人。
7. 中国医学科学院医学与健康科技创新工程项目(2016-2021)，感染性疾病（结核病等）诊治新策略研究，课题骨干。
8. 国家自然科学基金委员会面上项目(2012-2015)，接头蛋白Gab2调控结核病发生、发展的免疫学功能研究，课题负责人。
9. 国家科技重大专项 (2012-2015)，结核病分子标识的研究，课题负责人。
10. 国家科技重大专项(2008-2010)，结核病免疫保护机制研究，课题负责人。
11. 国家科技重大专项 (2008-2010)，结核病诊断分子标识研究，子课题负责人。
研究成果
1. Dong, H., Y. Zhang, Y. Zou, Y. Chen, J. Yue, H. Liu and X. Jiang (2021). "Elevated chemokines concentration is associated with disease activity in Takayasu arteritis." Cytokine 143: 155515.
2. Li, H., L. Liu, W. J. Zhang, X. Zhang, J. Zheng, L. Li, X. Zhu, Q. Yang, M. Zhang, H. Liu, X. Chen and Q. Jin (2019). "Analysis of the Antigenic Properties of Membrane Proteins of Mycobacterium tuberculosis." Sci Rep 9(1): 3042.
3. Liu, C. H., H. Liu and B. Ge (2017). "Innate immunity in tuberculosis: host defense vs pathogen evasion." Cell Mol Immunol 14(12): 963-975.
4. Hu, Y., Y. Zhang, X. Ren, Y. Liu, Y. Xiao, L. Li, F. Yang, H. Su, F. Liu, H. Liu, B. Cao and Q. Jin (2016). "A case report demonstrating the utility of next generation sequencing in analyzing serial samples from the lung following an infection with influenza A (H7N9) virus." J Clin Virol 76: 45-50.
5. Yu, Y., D. Jin, S. Hu, Y. Zhang, X. Zheng, J. Zheng, M. Liao, X. Chen, M. Graner, H. Liu and Q. Jin (2015). "A novel tuberculosis antigen identified from human tuberculosis granulomas." Mol Cell Proteomics 14(4): 1093-1103.
6. Zhang, M., G. Zeng, Q. Yang, J. Zhang, X. Zhu, Q. Chen, P. Suthakaran, Y. Zhang, Q. Deng, H. Liu, B. Zhou and X. Chen (2014). "Anti-tuberculosis treatment enhances the production of IL-22 through reducing the frequencies of regulatory B cell." Tuberculosis (Edinb) 94(3): 238-244.
7. Liu, L., W. J. Zhang, J. Zheng, H. Fu, Q. Chen, Z. Zhang, X. Chen, B. Zhou, L. Feng, H. Liu and Q. Jin (2014). "Exploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis." Mol Cell Proteomics 13(3): 897-906.
8. Hu, S., Y. Zhang, Y. Yu, D. Jin, X. Zhang, S. Gu, H. Jia, X. Chen, Z. Zhang, Q. Jin, Y. Ke and H. Liu (2014). "Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis." Am J Respir Cell Mol Biol 51(4): 575-585.
9. Zhang, Y., H. Liu, L. Wang, F. Yang, Y. Hu, X. Ren, G. Li, Y. Yang, S. Sun, Y. Li, X. Chen, X. Li and Q. Jin (2013). "Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease." PLoS One 8(6): e67430.
10. Yu, Y., Y. Zhang, S. Hu, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Different patterns of cytokines and chemokines combined with IFN-gamma production reflect Mycobacterium tuberculosis infection and disease." PLoS One 7(9): e44944.
11. Qiu, Z., M. Zhang, Y. Zhu, F. Zheng, P. Lu, H. Liu, M. W. Graner, B. Zhou and X. Chen (2012). "Multifunctional CD4 T cell responses in patients with active tuberculosis." Sci Rep 2: 216.
12. Liu, K., Y. Zhang, S. Hu, Y. Yu, Q. Yang, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis." PLoS One 7(6): e38429.
13. Zhang, M., Z. Wang, M. W. Graner, L. Yang, M. Liao, Q. Yang, J. Gou, Y. Zhu, C. Wu, H. Liu, B. Zhou and X. Chen (2011). "B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis." Cell Immunol 270(2): 217-223.
14. Bai, X., K. Chmura, A. R. Ovrutsky, R. P. Bowler, R. I. Scheinman, R. E. Oberley-Deegan, H. Liu, S. Shang, D. Ordway and E. D. Chan (2011). "Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription." Tuberculosis (Edinb) 91(1): 26-35.
15. Chen, X., M. Zhang, X. Zhu, Q. Deng, H. Liu, N. Larmonier, M. W. Graner and B. Zhou (2009). "Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy." J Infect Dis 200(3): 399-408.
16. Niedbala, W., B. Cai, H. Liu, N. Pitman, L. Chang, and F.Y. Liew, Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A, 2007. 104(39): p. 15478-83.
17. Liu, H. and B.P. Leung, CD4+CD25+ regulatory T cells in health and disease. Clin Exp Pharmacol Physiol, 2006. 33(5-6): p. 519-24.
18. Liu, H., M. Komai-Koma, D. Xu, and F.Y. Liew, Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A, 2006. 103(18): p. 7048-53.
19. Liew, F.Y., H. Liu, and D. Xu, A novel negative regulator for IL-1 receptor and Toll-like receptor 4. Immunol Lett, 2005. 96(1): p. 27-31.
20. Xu, D., H. Liu, and M. Komai-Koma, Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol, 2004. 1(4): p. 239-46.
21. Brint, E.K., D. Xu, H. Liu, A. Dunne, A.N. McKenzie, L.A. O'Neill, and F.Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol, 2004. 5(4): p. 373-9
22. Xu, D., H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew, CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol, 2003. 170(1): p. 394-9.
23. Liu, H., B. Hu, D. Xu, and F.Y. Liew, CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol, 2003. 171(10): p. 5012-7.
研究生培养
培养博士研究生4名，硕士研究生4名，3名硕士研究生在读。