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吴志强
研究员
导师类别：博士生导师
性别： 男
学历：博士研究生
学位：博士
个人简介
吴志强，男，博士，研究员，博士研究生导师
北京协和医学院病原生物学研究所课题组长
国家高层次人才特殊支持计划“万人计划”青年拔尖人才获得者
北京协和医学院“协和新星”
主持和承担国家科技重大专项、国家重点研发计划、国家自然科学基金和北京市自然科学基金等多项国家级和省部级课题；作为第一/通讯作者在The Lancet、National Science Review、Nature Communications、Microbiome、ISME Journal、Nucleic Acids Research、Journal of Virology等杂志发表SCI论文四十余篇；获得国家发明专利2项，软件著作权1项；获得省部级科技奖励二等奖2项，三等奖1项。
研究方向
动物源性新发病毒的监测、预警和溯源研究。
科研项目
1. 菲菊头蝠携带冠状病毒进化、重组及跨种适应特征研究，国家自然科学基金面上项目。
2. 潜在威胁人类病原体发现与挖掘-啮齿目、灵长目生态圈病原体广域调查与全链条挖掘，国家重点研发计划。
3. 蝙蝠携带病毒多样性及其跨种适应机制研究，国家重点研发计划。
4. 2019-nCoV溯源和传播途径研究，国家重点研发计划。
5. 以野生动物病毒组学为基础的新型冠状病毒溯源及其变异进化研究，北京市自然科学基金面上专项。
6. 我国周边地区重要传染病防控及处置能力提升研究，国家科技重大专项。
7. 中国代表性啮齿目及其他类小动物携带病毒的病毒组学研究，国家自然科学基金面上项目。
8. 我国蚊媒携带病毒组特征及传染病预警溯源关联研究，中国医学科学院中央级公益性科研院所基本科研业务费青年医学人才奖励项目。
9. 新型鼠源性砂粒病毒的鉴定及淋巴细胞脉络丛脑膜炎病毒的基因结构比较和进化研究，国家自然科学基金青年科学基金。
研究成果
1.Han Y, Xu P, Wang Y, Zhao W, Zhang J, Zhang S, Wang J, Jin Q, Wu Z. 2023. . Nat Commun 14:5537.
2. Wu Z, Han Y, Wang Y, Liu B, Zhao L, Zhang J, Su H, Zhao W, Liu L, Bai S, Dong J, Sun L, Zhu Y, Zhou S, Song Y, Sui H, Yang J, Wang J, Zhang S, Qian Z, Jin Q. 2023. A comprehensive survey of bat sarbecoviruses across China in relation to the origins of SARS-CoV and SARS-CoV-2. Natl Sci Rev 10:nwac213.
3. Su H, Wang Y, Han Y, Jin Q, Yang F, Wu Z. 2023. Discovery and characterization of novel paramyxoviruses from bat samples in China. Virol Sin 38:198-207.
4. Ou X, Xu G, Li P, Liu Y, Zan F, Liu P, Hu J, Lu X, Dong S, Zhou Y, Mu Z, Wu Z, Wang J, Jin Q, Liu P, Lu J, Wang X, Qian Z. 2023. Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses. Cell Discov 9:78.
5. Liu WJ, Lei W, He X, Liu P, Wang Q, Wu Z, Tan Y, Song S, Wong G, Lu J, Jiang J, Wei Q, Li M, Ma J, Peng X, Li Y, Huang B, Tong Y, Han J, Wu G. 2023. Back to Science in Searching for SARS-CoV-2 Origins. China CDC Wkly 5:315-317.
6. Li Y, Tang C, Zhang Y, Li Z, Wang G, Peng R, Huang Y, Hu X, Xin H, Feng B, Cao X, He Y, Guo T, He Y, Su H, Cui X, Niu L, Wu Z, Yang J, Yang F, Lu G, Gao L, Jin Q, Xiao M, Yin F, Du J. 2023. Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan, a tropical island of China. Virol Sin doi:10.1016/j.virs.2023.08.003.
7. Li P, Hu J, Liu Y, Ou X, Mu Z, Lu X, Zan F, Cao M, Tan L, Dong S, Zhou Y, Lu J, Jin Q, Wang J, Wu Z, Zhang Y, Qian Z. 2023. Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses. PLoS Pathog 19:e1011116.
8. Zhou S, Liu B, Han Y, Wang Y, Chen L, Wu Z, Yang J. 2022. ZOVER: the database of zoonotic and vector-borne viruses. Nucleic Acids Res 50:D943-d949.
9. Wu Z, Jin Q, Wu G, Lu J, Li M, Guo D, Lan K, Feng L, Qian Z, Ren L, Tan W, Xu W, Yang W, Wang J, Wang C. 2021. SARS-CoV-2's origin should be investigated worldwide for pandemic prevention. Lancet 398:1299-1303.
10. Wu Z, Han Y, Liu B, Li H, Zhu G, Latinne A, Dong J, Sun L, Su H, Liu L, Du J, Zhou S, Chen M, Kritiyakan A, Jittapalapong S, Chaisiri K, Buchy P, Duong V, Yang J, Jiang J, Xu X, Zhou H, Yang F, Irwin DM, Morand S, Daszak P, Wang J, Jin Q. 2021. Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia. Microbiome 9:18.
11. Wang G, Huang Y, Zhang W, Peng R, Luo J, Liu S, Bai S, Hu X, Wu Z, Yang F, Shen S, Zhang Y, Tang C, Cui X, Niu L, Lu G, Li S, Deng F, Zhang P, Du J, Yin F. 2021. Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China. Sci Rep 11:21018.
12. Liu Y, Liu B, Liu C, Hu Y, Liu C, Li X, Li X, Zhang X, Irwin DM, Wu Z, Chen Z, Jin Q, Zhang S. 2021. Differences in the gut microbiomes of dogs and wolves: roles of antibiotics and starch. BMC Vet Res 17:112.
13. Li P, Guo R, Liu Y, Zhang Y, Hu J, Ou X, Mi D, Chen T, Mu Z, Han Y, Chen Z, Cui Z, Zhang L, Wang X, Wu Z, Wang J, Jin Q, Qian Z. 2021. The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2. Sci Bull (Beijing) 66:1215-1227.
14. Ren LL, Wang YM, Wu ZQ, Xiang ZC, Guo L, Xu T, Jiang YZ, Xiong Y, Li YJ, Li XW, Li H, Fan GH, Gu XY, Xiao Y, Gao H, Xu JY, Yang F, Wang XM, Wu C, Chen L, Liu YW, Liu B, Yang J, Wang XR, Dong J, Li L, Huang CL, Zhao JP, Hu Y, Cheng ZS, Liu LL, Qian ZH, Qin C, Jin Q, Cao B, Wang JW. 2020. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl) 133:1015-1024.
15. Li F, Du J, Wu Z, Zhang W, Fu S, Song J, Wang Q, He Y, Lei W, Xu S, Xu A, Zhao L, Liang G, Wang H. 2020. Identification and genetic analysis of a totivirus isolated from the Culex tritaeniorhynchus in northern China. Arch Microbiol 202:807-813.
16. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avši?-?upanc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartoni?ka T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, et al. 2020. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol 165:3023-3072.
17. Du J, Li F, Han Y, Fu S, Liu B, Shao N, Su H, Zhang W, Zheng D, Lei W, Dong J, Sun L, He Y, Wang J, Yang F, Wang H, Liang G, Wu Z, Jin Q. 2020. Characterization of viromes within mosquito species in China. Sci China Life Sci 63:1089-1092.
18. Han Y, Du J, Su H, Zhang J, Zhu G, Zhang S, Wu Z, Jin Q. 2019. Identification of Diverse Bat Alphacoronaviruses and Betacoronaviruses in China Provides New Insights Into the Evolution and Origin of Coronavirus-Related Diseases. Front Microbiol 10:1900.
19. Wu Z, Lu L, Du J, Yang L, Ren X, Liu B, Jiang J, Yang J, Dong J, Sun L, Zhu Y, Li Y, Zheng D, Zhang C, Su H, Zheng Y, Zhou H, Zhu G, Li H, Chmura A, Yang F, Daszak P, Wang J, Liu Q, Jin Q. 2018. Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases. Microbiome 6:178.
20. Wu Z, Liu B, Du J, Zhang J, Lu L, Zhu G, Han Y, Su H, Yang L, Zhang S, Liu Q, Jin Q. 2018. Discovery of Diverse Rodent and Bat Pestiviruses With Distinct Genomic and Phylogenetic Characteristics in Several Chinese Provinces. Front Microbiol 9:2562.
21. Wu Z, Du J, Lu L, Yang L, Dong J, Sun L, Zhu Y, Liu Q, Jin Q. 2018. Detection of Hantaviruses and Arenaviruzses in three-toed jerboas from the Inner Mongolia Autonomous Region, China. Emerg Microbes Infect 7:35.
22. Maes P, Alkhovsky SV, Bào Y, Beer M, Birkhead M, Briese T, Buchmeier MJ, Calisher CH, Charrel RN, Choi IR, Clegg CS, de la Torre JC, Delwart E, DeRisi JL, Di Bello PL, Di Serio F, Digiaro M, Dolja VV, Drosten C, Druciarek TZ, Du J, Ebihara H, Elbeaino T, Gergerich RC, Gillis AN, Gonzalez JJ, Haenni AL, Hepojoki J, Hetzel U, H? T, Hóng N, Jain RK, Jansen van Vuren P, Jin Q, Jonson MG, Junglen S, Keller KE, Kemp A, Kipar A, Kondov NO, Koonin EV, Kormelink R, Korzyukov Y, Krupovic M, Lambert AJ, Laney AG, LeBreton M, Lukashevich IS, Marklewitz M, Markotter W, et al. 2018. Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018. Arch Virol 163:2295-2310.
23. Du J, Li Y, Lu L, Zheng D, Liu B, Yang L, Su H, Dong J, Sun L, Zhu Y, Yang J, Yang F, Zhang X, Liu Q, Wu Z, Jin Q. 2018. Biodiversity of rodent anelloviruses in China. Emerg Microbes Infect 7:38.
24. Xiu L, Zhang C, Wu Z, Peng J. 2017. Establishment and Application of a Universal Coronavirus Screening Method Using MALDI-TOF Mass Spectrometry. Front Microbiol 8:1510.
25. Chen L, Liu B, Wu Z, Jin Q, Yang J. 2017. DRodVir: A resource for exploring the virome diversity in rodents. J Genet Genomics 44:259-264.
26. Wu Z, Yang L, Ren X, Zhang J, Yang F, Zhang S, Jin Q. 2016. ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. J Infect Dis 213:579-83.
27. Wu Z, Yang L, Ren X, He G, Zhang J, Yang J, Qian Z, Dong J, Sun L, Zhu Y, Du J, Yang F, Zhang S, Jin Q. 2016. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. Isme j 10:609-20.
28. Du J, Yang L, Ren X, Zhang J, Dong J, Sun L, Zhu Y, Yang F, Zhang S, Wu Z, Jin Q. 2016. Genetic diversity of coronaviruses in Miniopterus fuliginosus bats. Sci China Life Sci 59:604-14.
29. Du J, Lu L, Liu F, Su H, Dong J, Sun L, Zhu Y, Ren X, Yang F, Guo F, Liu Q, Wu Z, Jin Q. 2016. Distribution and characteristics of rodent picornaviruses in China. Sci Rep 6:34381.
30. Li JL, Yuan J, Yang F, Wu ZQ, Hu YF, Xue Y, Zhou BP, Jin Q. 2014. Epidemic characteristics of hand, foot, and mouth disease in southern China, 2013: coxsackievirus A6 has emerged as the predominant causative agent. J Infect 69:299-303.
31. Wu Z, Du J, Zhang T, Xue Y, Yang F, Jin Q. 2013. Recombinant human coxsackievirus B3 from children with acute myocarditis in China. J Clin Microbiol 51:3083-6.
32. Wang J, Du J, Wu Z, Jin Q. 2013. Quinacrine impairs enterovirus 71 RNA replication by preventing binding of polypyrimidine-tract binding protein with internal ribosome entry sites. PLoS One 8:e52954.
33. Du J, Wu Z, Xue Y, Zhang T, Yang F, Jin Q. 2013. Complete genome sequence of a human coxsackievirus b3 from a child with myocarditis in beijing, china. Genome Announc 1.
34. Zhang T, Wu Z, Du J, Hu Y, Liu L, Yang F, Jin Q. 2012. Anti-Japanese-encephalitis-viral effects of kaempferol and daidzin and their RNA-binding characteristics. PLoS One 7:e30259.
35. Wu Z, Ren X, Yang L, Hu Y, Yang J, He G, Zhang J, Dong J, Sun L, Du J, Liu L, Xue Y, Wang J, Yang F, Zhang S, Jin Q. 2012. Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J Virol 86:10999-1012.
36. Wang J, Wu Z, Jin Q. 2012. COPI is required for enterovirus 71 replication. PLoS One 7:e38035.
37. Chen LH, Wu ZQ, Hu YF, Yang F, Yang J, Jin Q. 2012. [Genetic diversity of adenoviruses in bats of China]. Bing Du Xue Bao 28:403-8.
38. Yang J, Yang F, Ren L, Xiong Z, Wu Z, Dong J, Sun L, Zhang T, Hu Y, Du J, Wang J, Jin Q. 2011. Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J Clin Microbiol 49:3463-9.
39. Wu Z, Xue Y, Wang B, Du J, Jin Q. 2011. Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons. PLoS One 6:e26304.
40. Wang J, Fan T, Yao X, Wu Z, Guo L, Lei X, Wang J, Wang M, Jin Q, Cui S. 2011. Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 85:10021-30.
41. Zhiqiang W, Yaowu Y, Fan Y, Jian Y, Yongfeng H, Lina Z, Jianwei W, Qi J. 2010. Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus. Antiviral Res 85:559-61.
42. Wu Z, Yang F, Zhao R, Zhao L, Guo D, Jin Q. 2009. Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China. J Virol Methods 159:233-8.
研究生培养
在读博士研究生：韩业林（2021级），黎蕊（2022级），赵腊梅（2023级），于秀娟（2023级）
在读硕士研究生：许盼盼（2021级）。
已毕业博士研究生：杜江（2014级），王宇洋（2020级）。
已毕业硕士研究生：韩业林（2017级）
1人次获得国家奖学金，2人次获得一等奖学金、优秀研究生，2人次获得北京协和医学院中央高校基本科研业务费（学生项目）资助。